EVALUATION OF ANTIOXIDANT PROPERTIES OF EUODIA HORTENSIS FORSTER EXTRACTS ON BRAIN ENZYMES LEVEL IN RATS
The stems of Euodia hortensis Forster is used traditional Indian medicine to treat epilepsy.Previous studies have demonstrated that extracts of these plants was subjected to acute toxicity and then screened for antiepileptic activity on Maximal Electroshock (MES) and Pentylenetetrazole (PTZ) induced seizures models in albino wistar rats. The purpose of the present study is to investigate the effect of ethanolic (95%) extract of Euodia hortensis Forster (EEEH) on antioxidant enzymes in rat brain after induction of seizures by MES and PTZ. Our ai m of study was relationship between seizure activities and altered the levels of antioxidant enzymes such as superoxide dismutase (SOD), glutathione peroxidase (GP), glutathione reductase (GR), catalase and lipid peroxidation on rat brain. Superoxide dismutase, glutathione peroxidase, glutathione reductase and catalase was decreased in rat brain due to seizure and it was restored significantly by administration of ethanol extract of Euodia hortensis Forster treated rats. Similar dose dependent results were obtained in PTZ model also. Whereas EEEH significantly decreased lipid peroxidation in both models. The anticonvulsant activity of EEEH might be presents of antioxidant properties and it delays the generation of free radical in MES & PTZ induced epilepsy.