EVALUATION OF ANTIOXIDANT AND ANTIBACTERIAL ACTIVITY OF TERMINALIA CHEBULA FRUIT EXTRACT
The present study is the continuation of a program aimed at investigation of antimicrobial properties of Terminalia chebula fruit extract to justify the traditional claim endowed upon this herbal drug as a rasayana in Ayurveda. The antimicrobial activity was evaluated according to the disk diffusion method by using Gram positive; B. subtilius, S. aureus and S. epidermidis and Gram Negative; E. coli S. flexineri, P. aeruginosa bacteria. This study show that methanolic fruits extract of Terminalia chebula Linn inhibits the growth of micro organism dose dependently. The antioxidant activity of Terminalia chebula fruit extract using Fenton reaction was also observed and we found a dose dependent inhibition of Thiobarbituric acid reactive substance (TBARS) as compared to positive control. The results of the effects of the examined Terminalia chebula fruit extract as well as control solutions on OH- radical production. They show that all extract of Terminalia chebula and control solutions as a DMSO inhibited the production of OH- radicals.These results confirm the antibacterial activity of Terminalia chebula leaves and support the traditional use of the plant in therapy of bacterial infection. These promising findings suggest the presence of antibacterial activity in the tested plant material, exhibited by its bioactive compounds, and serving them as an alternative antimicrobial agent.