ANTIHYPERGLYCEMIC AND ANTIHYPERLIPIDEMIC ACTIVITIES OF ETHANOLIC EXTRACTS OF CASSIA SOPHERA (L.) IN ALLOXAN INDUCED DIABETES MICE
The aim of the investigation was to investigate the hypoglycemic and hypolipidemic activity of ethanolic extracts of different parts (fruits and stems) from the plant Cassia sophera in alloxan-‘,induced diabetic mice. 20 mice were used for a week-long anti-hyperglycemic test. Lipid profile analysis was performed by estimating total cholesterol (TC), triglyceride (TG), phospholipid and liver glycogen concentration on 20 mice after week -long antihyperglycemic tested mice. Metformin Hcl (150mg/kg body weight, op. ) was used as a standard antidiabetic agent. The result indicated that after oral ingestion of Cassia sophera(CS) extracts for seven days in diabetic mice, Group-DCF and Group-DCS mice showed significantly (p<0.05) reduced bloodglucose levels 47.23% and62.13% respectively at the dose 300 mg/kg body weight when compared to Group -DC mice. Short-term treatment with extracts had no effect on body weight to organ weight ratio; however, it significantly lowered liver weight in Group DCF and Group-DCS. Administration of extracts greatly reduced both the serum cholesterol and triglycerides and phospholipids levels in Group-DCF and Group-DCS. Liver glycogen content significantly restored in Group-DCF and Group-DCS compared to Group-DC mice. The present investigation established the pharmacological evidence to support the folklore claim and that the plant parts have anti-diabetic and hypo-lipidemic potential.