ANTIUROLITHIATIC EFFECT OF BRYOPHYLLUM PINNATUM ON ETHYLENE GLYCOL INDUCED UROLITHIASIS
Research Scholar, Institute of Pharmaceutical Science & Research Center, Bhagwant University, Ajmer, Rajasthan, India-305004
Principal, Rajeev Gandhi College of Pharmacy, Bhopal, Madhya Pradesh, India-462042
Urinary stone disease continues to occupy an important place in everyday urological practice. The average life time risk of stone formation has been reported in the range of 5 -10 %. The conventional dosage forms have a number of side effects and their prolonged use leads to toxicity. The present study was undertaken to evaluate the Alcoholic Bryophyllum pinnatum (ABP) for its effects on ethylene glycol induced urolithiasis in rats. In this study the ethanolic extracts of Bryophyllum pinnatum was used to study urolithiatic activity. Urolithiatic activity was assessed using ethylene glycol induced urolithiatic model. The data of urinary, renal and serum parameters were expressed as mean ± SEM. The results were analyzed statistically using ANOVA followed by Dunnett’s t -test. The minimum level of significance was fixed at p<0.05. The results shows that ABP (Alcoholic Bryophyllum pinnatum) shows antiurolithiatic activity at significant level (p<0.05). The increase in urinary calcium, oxalate and phosphate were normalized by Alcoholic Bryophyllum pinnatum and also increase in serum creatinine and uric acid as a result of ethylene glycol treatment was normalized by Alcoholic Bryophyllum pinnatum. Thus we can conclude that Alcoholic Bryophyllum pinnatum showed promising antiurolithiatic activity.
3 , 2 , 2013
78 - 81