WOUND HEALING ACTIVITY OF ETHANOLIC EXTRACT OF POLYALTHIA LONGIFOLIA LEAVES IN EXCISION WOUND MODEL IN RATS
Balamuruganvelu S
Department of Microbiology, 6 Department of Pharmacology, Sri Lakshmi Narayanan Institute of Medical Sciences, Pondicherry, India
Geethavani B
Department of Microbiology, 6 Department of Pharmacology, Sri Lakshmi Narayanan Institute of Medical Sciences, Pondicherry, India
Premlal KR
Division of Oral Pathology, Rajah Muthiah Dental College &Hospital, Annamalai University, Chidambaram, Tamilnadu, India
Shanmugasundaram P
Department of Orthopedics, Saveetha Medical College, Chennai, Tamilnadu, India
Kalyani M
Department of Microbiology, Madha Medical College, Chennai, Tamilnadu, India
Shakthi Dasan S
Department of Biochemistry, Melmaravathur Adhi Parasakthi Institute of Medical Sciences and Research, Melmaravathur, Tamilnadu, India.
Jaikumar S
Department of Biochemistry, Melmaravathur Adhi Parasakthi Institute of Medical Sciences and Research, Melmaravathur, Tamilnadu, India.
The present study was conducted to evaluate the wound healing effect of Polyalthia longifolia leaf extract in excision wound model in rats. The ethanolic leaf extract of Polyalthia longifolia (5% and 10%) were topically applied and the wound healing potential was evaluated in rats. The wound healing efficacy was studied by using excision wound model, which was inflicted by cutting away 500 mm 2 of the skin on the anterio – dorsal side of the rats. Povidone iodine ointment was used as reference standard. Wound healing property, based on wound contraction was measured and assessed up to 14 days. The topical application of ethanolic leaf extract of Polyalthia longifolia (5% and 10%) had promoted wound healing in rats. There was significant contraction of wound observed with topical application of ethanolic leaf extract at both doses of Polyalthia longifolia in rats. Further phytochemical studies are required to isolate the active compounds responsible for these pharmacological actions.
4 , 3 , 2014
133 - 135