EVALUATION OF IMMUNOMODULATORY ACTIVITY ON BOUGAINVILLEA GLABRA LEAVES USING METHANOLIC EXTRACT
P. Rajeshwari
Department of Pharmacology, Faculty of Pharmacy, Rao’s College of Pharmacy, Chemudugunta (v&po), Venkatachalam, Nellore, Andhra Pradesh, 524 320, India
N. Naga Preethi
Department of Pharmacology, Faculty of Pharmacy, Rao’s College of Pharmacy, Chemudugunta (v&po), Venkatachalam, Nellore, Andhra Pradesh, 524 320, India
To evaluate immunomodulatory activity on Bougainvillea glabra leaves using methanolic extract in swiss albino rat. The specific humoral immunity, cell mediated immunity was assessed by performing hemagglutinating antibody titer (H.A. Titer), delayed type hypersensitivity (DTH) and the non Specific immunity was assessed by performing carbon clearance test, neutrophil adhesion test and biochemical parameters (SGPT, SGOT) are also used. The methanolic leaf extract of Bougainvillea glabra (MLBG) high dose was found equal effect compare to standard drug levamisole in delayed type hypersensitive reaction (DTH), neutrophil adhesion test, carbon clearance test, humoral antibody titer and biochemical parameters. Present study, therefore, reveals that (MLBG) holds promise as immunodulatory agent in comparision to the standard drug Levamisole
6 , 1 , 2016
18 - 24