DESIGN AND EVALUATION OF KAEMPFEROL INCORPORATED OPTHALMIC GELS
K. Susmitha*, VV. Akshitha
Department of Pharmaceutics, Saastra College of Pharmaceutical Education and Research Varigonda village, T.P.Gudur, SPSR Nellore Dt-524311
D. Sireesha, V. Siva Raghavendra
Department of Pharmaceutics, Saastra College of Pharmaceutical Education and Research Varigonda village, T.P.Gudur, SPSR Nellore Dt-524311
M. Pawan Kalyan, K. Maneesha
Department of Pharmaceutics, Saastra College of Pharmaceutical Education and Research Varigonda village, T.P.Gudur, SPSR Nellore Dt-524311
The method or process of providing a pharmaceutical substance to create a therapeutic effect in people or animals is referred to as drug delivery. Drug release profiles, absorption, distribution, and elimination are all affected by drug delivery systems. In practise, the intraocular approach is more difficult to apply. Researchers are currently focused on the development of intravitreal injections and the use of intraocular implants to improve delivery to the eye. In situ forming gels are formulations that gel after instillation due to physicochemical changes in the eye whether given as solutions, sols, or suspensions. This study's purpose is to develop and evaluate an insitu Kaempferol gel. The gelling chemical Carbopol and the viscosity-increasing compound HPMC were used to form an in situ gel. Gel pH, gel capacity, clarity, drug content, viscosity, and in-vitro drug release assays were used to examine the gel in situ. All of the parameters were found to be within their specified ranges. In-situ gel properties did not change significantly with ageing under various storage conditions, according to the stability studies. The current research suggests that Kaempferol in-situ gels can exhibit controlled release with stability, and that the optimised formulations Carbopol-940 and HPMCK100 (0.6g and 0.5g) meet the study's goals of reduced administration frequency and improved patient compliance
12 , 1 , 2022
9 - 12