DEVELOPMENT OF FORMULATION AND EVALUATION OF PHYTOSOMAL GEL OF NEEM
Dr. Vasuki K1*, Dr. Manivannan R2, Abinaya R, Pavithra M, Tamilselvan S, Vimalya S
Professor, Department of Pharmacognosy, Excel College of Pharmacy, Komarapalayam, Namakkal Dt,
Tamil Nadu - 638 183, India.
2Principal, Excel College of Pharmacy, Komarapalayam, Namakkal Dt, Tamilnadu - 638 183, India.
3UG Scholars, Excel College of Ph
Phytosomes of neem leave extract has been successfully formulated in this procedure firstly Azadirachta indica leaves were morphological Characterized. Neem leave powder was subjected for various physiochemical analysis and extracted out methanolic fraction of neem leaves, yield of the extract which was 6.93%. Phytochemical screening found that carbohydrate, alkaloids and flavonoids were present. Phytosome formulation was formed using different ratio of Phosphatidylcholine and Cholesterol (4:1). This formulation was characterized under various parameters like yield, drug content and encapsulation efficiency. The formulation yield was 71.15 %, drug content was 88.11% and encapsulation efficiency was 72.31%. Phytosome formulation was incorporated with gel and evaluated under the various parameters, pH 6.6, viscosity 98 centipoises (cp) of formulation was observed and spreadability between 5.6cm
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